Homocyst(e)ine and atherosclerosis in patients on chronic hemodialysis.
10.3346/jkms.1999.14.2.193
- Author:
Young Ki LEE
1
;
Young Joo KWON
;
Jong Woo YOON
;
Kyung Sik OH
;
Dae Ryong CHA
;
Won Yong CHO
;
Kuhl HUH
;
Heui Jung PYO
;
Hyoung Kyu KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Korea University, Seoul.
- Publication Type:Original Article
- Keywords:
Atherosclerosis;
Dialysis;
Homocystein
- MeSH:
Adolescence;
Adult;
Aged;
Arteriosclerosis/etiology*;
Chronic Disease;
Female;
Homocysteine/blood*;
Homocystine/blood*;
Human;
Hyperhomocysteinemia/physiopathology*;
Male;
Middle Age;
Renal Dialysis*;
Risk Factors
- From:Journal of Korean Medical Science
1999;14(2):193-198
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hyperhomocyst(e)inemia is an established risk factor for atherosclerosis. We performed this study to identify the correlating variables and risk factors for atherosclerosis, as measured by the atherosclerotic score (AS), and to determine the relative risk for cardiovascular disease in relation to plasma homocyst(e)ine levels in patients on chronic hemodialysis. We evaluated and measured 61 patients on chronic hemodialysis for clinical and biochemical parameters including atherosclerotic score (AS) and plasma homocyst(e)ine. We divided patients into high and low groups, first, by the mean AS, and second, by the median value of plasma total homocyst(e)ine levels. Then we compared the variables between the two groups. Out of the 61 patients, the median plasma total homocyst(e)ine level was 24.4 micromol/L (mean+/-SD, 27.7+/-17.4; range, 9.8-127.4 micromol/L), and the median AS was 5 (mean+/-SD, 6.2+/-2.8; range, 3-13) out of a possible 20 points. AS was significantly correlated with plasma total homocyst(e)ine levels (r=0.37) and age (r=0.67). Through multivariate analysis, plasma total homocyst(e)ine level and age were determined as significant risk factors for the high-AS group (p<0.05). However, plasma total homocyst(e)ine level did not correlate with age (p>0.05). Eighteen of the 61 patients, presented with cardiovascular disease until the present study, had an AS>6. Cardiovascular disease was found more often in the high-homocyst(e)ine group (>24.4 micromol/L) than in the low-homocyst(e)ine group (odds ratio, 9.3; 95% confidence interval, 2.3-37.4). Regardless of age, hyperhomocyst(e)inemia (especially homocyst(e)ine levels >24.4 micromol/L) is a risk factor that can be modified for the development of cardiovascular disease in patients on chronic hemodialysis.
