A Case of Anti-glomerular Basement Membrane Antibody mediated Rapidly Progressive Glomerulonephritis.
- Author:
Seung Won LEE
1
;
Yon Sil JUNG
;
Pill Woon KIM
;
Ji Ho CHOI
;
Tae Seog KIM
;
Mi Kyung CHA
;
Jong Ho LEE
;
Seung Yeon HA
;
Moon Hyang PARK
Author Information
1. Department of Internal Medicine, Chungang Gil Hospital, Inchon, Korea.
- Publication Type:Case Report
- Keywords:
Anti-glomerular basement membrane antibody;
Rapidly progressive glomerulonephritis
- MeSH:
Autoantibodies;
Basement Membrane*;
Biopsy;
Enzyme-Linked Immunosorbent Assay;
Female;
Fever;
Glomerular Basement Membrane;
Glomerulonephritis*;
Hematocrit;
Humans;
Immunoglobulin G;
Middle Aged;
Plasmapheresis;
Renal Insufficiency;
Urinalysis
- From:Korean Journal of Nephrology
1998;17(1):151-156
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-glomerular basement membrane antibody mediated rapidly progressive glomerulonephritis(anti- GBM antibody mediated RPGN) is defined by the clinical picture of renal failure developing over days or weeks and the histological appearance of crescents and linear immune deposits mediated by the circulating autoantibodies. We report a case of anti-GBM antibody mediated RPGN with review of literature. A 59-year-old female patient was admitted to the Chungang Gil Hospital because of fever and acute deterioration of renal function. On admission, hemoglobin was 7.39g/dL, hematocrit was 20.9%, and BUN/Cr were 39.7 and 5.23mg/dL respectively. Urinalysis showed albumin (1+) with many RBCs. Renal biopsy revealed the presence of segmental or circumferential cellular crescents associated with smooth linear staining of glomerular basement membrane with antibody to IgG. High titer of circulating antibody to glomerular basement membrane antigen was demonstrated by the ELISA. High doses of corticosteroid with plasmapheresis were administered, but her renal function was progressively deteriorated.
