Changes of Souble ICAM-1 Levels in Patients with Tsutsugamushi Disease.
- Author:
Heung Bum LEE
1
;
Hyeon Woo KOH
;
Hyong Sik KIM
;
Sung Gi MOON
;
Sang Mi OH
;
Yong Chul LEE
;
Yang Keun RHEE
Author Information
1. Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Korea.
- Publication Type:Original Article
- Keywords:
sICAM-1;
Tsutsugamushi disease;
Correlation
- MeSH:
Asthma;
Communicable Diseases;
Enzyme-Linked Immunosorbent Assay;
Fever;
Humans;
Intercellular Adhesion Molecule-1*;
Leukocyte Count;
Leukocytes;
Malaria;
Scrub Typhus*;
Tuberculosis
- From:Korean Journal of Medicine
1998;54(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: ICAM-1 has been shown to be required for leukocyte migration into inflammed area and plays a significant role in inflammatory disease including bronchial asthma, and various infectious disease such as tuberculosis and malaria. Although, the significance of soluble ICAM-1(sICAM-1) in rickettial disease has not been recognized. The present investigation was designed to evaluate the sICAM-1 levels in patients with tsutsugamushi disease, and the correlation factors between sICAM-1 level and subject characteristics including clinical and laboratory indices. METHODS: Eight normal controls and thirteen patients with tsutsugamushi disease underwent serum sampling for sICAM-1 level, which was measured by using ELISA kit. RESULTS: 1) sICAM-1 level is significantly elevated in patients group. 2) sICAM-1 level is a significantly correlation with AST level, titer of anti-tsutsugamushi antiboby, and leukocyte counts, but other factors such as age, sex, differential fraction of leukocyte, ALT, duration of fever, and total hospital day etc, are not. CONCLUSION: These results show that sICAM-1 may be a role in the pathogenesis of tsutsugamushi disease.
