Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia.
10.4046/trd.2015.78.4.401
- Author:
Ji Hyun OH
1
;
Dong Jun OH
;
So My KOO
;
Yang Ki KIM
;
Ki Up KIM
;
Hyun Jo KIM
;
Dong Won KIM
;
Soo Taek UH
Author Information
1. Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea. uhs@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Cryptogenic Organizing Pneumonia;
Clarithromycin;
Macrolides;
Adrenal Cortex Hormones
- MeSH:
Adrenal Cortex Hormones;
Clarithromycin*;
Cryptogenic Organizing Pneumonia*;
Fibrosis;
Humans;
Idiopathic Interstitial Pneumonias;
Lung;
Macrolides;
Prognosis;
Steroids;
Treatment Failure
- From:Tuberculosis and Respiratory Diseases
2015;78(4):401-407
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids. A few reports showed treatment failure with macrolides in patients with COP who were resistant to steroids. In this report, we described two cases of COP who showed different responses to clarithromycin. One recovered completely, but the other gradually showed lung fibrosis with clarithromycin.
