Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report.
10.4046/trd.2015.78.4.463
- Author:
Yeun Seoung CHOI
1
;
Jung Soo LIM
;
Woocheol KWON
;
Soon Hee JUNG
;
Il Hwan PARK
;
Myoung Kyu LEE
;
Won Yeon LEE
;
Suk Joong YONG
;
Seok Jeong LEE
;
Ye Ryung JUNG
;
Jiwon CHOI
;
Ji Sun CHOI
;
Joon Taek JEONG
;
Jin Sae YOO
;
Sang Ha KIM
Author Information
1. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. sanghakim@yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Histiocytosis, Langerhans-Cell;
Cystic Disease of Lung;
Diabetes Insipidus;
Diabetes Mellitus;
Smoking Cessation
- MeSH:
Adult*;
Biopsy;
Cough;
Diabetes Insipidus;
Diabetes Insipidus, Neurogenic*;
Diabetes Mellitus*;
Diabetes Mellitus, Type 2;
Dyspnea;
Follow-Up Studies;
Histiocytosis, Langerhans-Cell*;
Humans;
Lung;
Lung Diseases;
Magnetic Resonance Imaging;
Male*;
Polydipsia;
Smoke;
Smoking;
Smoking Cessation;
Thoracic Surgery, Video-Assisted;
Water Deprivation
- From:Tuberculosis and Respiratory Diseases
2015;78(4):463-468
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.
