Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice.
10.5625/lar.2014.30.4.151
- Author:
Hak Yong LEE
1
;
Kwang Hyun PARK
;
Young Mi PARK
;
Dae In MOON
;
Hong Geun OH
;
Dae Young KWON
;
Hye Jeong YANG
;
Okjin KIM
;
Dong Woo KIM
;
Ji Hyun YOO
;
Se Chul HONG
;
Kun Hee LEE
;
Su Yeon SEOL
;
Yong Sik PARK
;
Jong Dae PARK
;
Mi Kyung PYO
Author Information
1. Huvet Co., Ltd., Iksan, Korea.
- Publication Type:Original Article
- Keywords:
High fat diet;
red ginseng extract;
hyperglycemia;
dyslipidemia
- MeSH:
Adipocytes;
Adipogenesis;
Animals;
Biological Availability;
Blood Glucose;
Cholesterol;
Diet;
Diet, High-Fat;
Dietary Supplements;
Dyslipidemias;
Fatty Liver;
Functional Food;
Hyperglycemia;
Leptin;
Mice;
Mice, Obese*;
Models, Animal;
Obesity;
Panax*
- From:Laboratory Animal Research
2014;30(4):151-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
Red ginseng and its extracts have been used as traditional medicines and functional foods in countries worldwide. The aim of this study was to examine the bioavailability of pectin lyase-modified red ginseng extracts (GS-E3D), and the effects of GS-E3D on adipogenesis of 3T3-L1 adipocytes, as well as on metabolic disorders such as hyperglycemia, dyslipidemia, and fatty liver in high-fat diet fed obese C57BL/6 mice. Mice were divided into 5 groups: normal diet group, high fat diet-vehicle group, high fat diet + 0.1 g/kg GS-E3D (0.1-GS-E3D), high fat diet + 0.3 g/kg (0.3-GS-E3D), high fat diet + 1.0 g/kg (1.0-GS-E3D). Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity. In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner. In addition, we found that GS-E3D could decrease total hepatic lipid droplets. These results suggest that GS-E3D, as a dietary supplement, has beneficial effects on obesity and may have useful effects in health-care products.
