A Case of Cyclic Thrombocytopenia: A Case Report.
- Author:
Eun Ha LEE
1
;
Sang Gyung KIM
;
Hun Suk SUH
;
Dong Gun SHIN
Author Information
1. Department of Clinical Pathology, College of Medicine, Catholic University of Taegu-Hyosung, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Cyclic thrombocytopenia;
Periodic destruction;
Megakaryocytopoiesis
- MeSH:
Blood Platelets;
Bone Marrow;
Female;
Humans;
Megakaryocytes;
Platelet Count;
Thrombocytopenia*;
Thrombopoiesis;
Young Adult
- From:Korean Journal of Clinical Pathology
1999;19(1):15-18
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cyclic thrombocytopenia is a rare disorder with cyclic change of the platelet counts. Although the pathogenesis of the disorder has not been clarified, recent reports suggest that periodic destruction and/or ineffective production of platelets may be important causes of the disease. We report a 24-year-old female with the episodes of severe thrombocytopenia (minimum platelet count 2x109/L) followed by normal or higher platelet counts (maximum platelet count 877x109/L). The period of platelet count fluctuation was about 20-40 days. Morphological examination of bone marrow showed the cyclic disappearance of mature and immature megakaryocytes. These findings indicate that the cause of platelet fluctuation is periodic failure of megakaryocytopoiesis.
