Insights into the Transforming Growth Factor-beta Signaling Pathway in Cutaneous Melanoma.
- Author:
Carole Yolande PERROT
1
;
Delphine JAVELAUD
;
Alain MAUVIEL
Author Information
- Publication Type:Review
- Keywords: Melanoma; Metastasis; TGF-beta signaling; Therapeutic-targets
- MeSH: Cell Movement; Embryonic Development; Epithelial Cells; Female; Homeostasis; Melanoma; Neoplasm Metastasis; Pregnancy; Robenidine; Tissue Distribution; Transforming Growth Factor beta; United Nations
- From:Annals of Dermatology 2013;25(2):135-144
- CountryRepublic of Korea
- Language:English
- Abstract: Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-beta signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-beta is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-beta signaling in melanoma.
