Epidermal Necrolysis due to Methazolamide Treatment in Glaucomatous Patients.
- Author:
Min Sung KIM
1
;
Hoon CHOI
;
Bong Seok SHIN
;
Kyu Chul CHOI
Author Information
1. Department of Dermatology, Chosun University Medical School, Gwangju, Korea. kcchoi@chosun.ac.kr
- Publication Type:Case Report
- Keywords:
Epidermal necrolysis;
Methazolamide
- MeSH:
Acidosis;
Carbonic Anhydrases;
Humans;
Hypokalemia;
Intraocular Pressure;
Methazolamide;
Myopia;
Necrosis;
Tinnitus
- From:Korean Journal of Dermatology
2011;49(6):533-537
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Epidermal necrolysis (EN) is a rare, but potentially life threatening disease, characterized by epidermal necrosis and sub-epidermal detatchment, and is predominantly medication-induced. Methazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used for lowering of intraocular pressure in glucomatous patients. Common side effects of methazolamide include metabolic acidosis, hypokalemia, tinnitus, transient myopia, and renal calculi; however, EN caused by methazolamide is very rare. We report on two cases of EN induced by methazolamide treatment and review previously published cases.
