A Case of Hypersensitivity Pneumonitis Caused by Methotrexate.
10.4046/trd.2004.56.2.203
- Author:
Hyun Joo SUH
1
;
Eun Ha PARK
;
Man Pyo CHUNG
;
Sung Chul SHIN
;
Kyeong Man JEON
;
Chang Min YU
;
Yu Jang PYUN
;
Kyung Soo LEE
;
Joungho HAN
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-Dong, Kangnam-Ku, Seoul, Korea. mpchung@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Methotrexate;
Hypersensitivity pneumonitis
- MeSH:
Alveolitis, Extrinsic Allergic*;
Arthritis, Rheumatoid;
Cryptogenic Organizing Pneumonia;
Granuloma;
Humans;
Hypersensitivity*;
Korea;
Lung Diseases;
Lung Diseases, Interstitial;
Lung Injury;
Lymphoma, Non-Hodgkin;
Methotrexate*;
Osteosarcoma;
Pneumonia;
Psoriasis;
Sarcoidosis;
Wegener Granulomatosis
- From:Tuberculosis and Respiratory Diseases
2004;56(2):203-209
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Methotrexate (MTX) has been used to treat a wide range of malignant and benign diseases including osteosarcoma, advanced stage non-Hodgkin's lymphoma, psoriasis, severe rheumatoid arthritis, sarcoidosis, and Wegener's granulomatosis. MTX-induced lung injury occurs in up to 10% of treated patients. Although both acute and chronic presentations have been described, typical manifestation of MTX-induced lung injury is subacute with symptoms usually developing within several months after starting therapy. Nonspecific interstitial pneumonia (NSIP) is the most common histopathologic manifestation of MTX-induced lung disease, while bronchiolitis obliterans organizing pneumonia (BOOP) and diffuse alveolar damage (DAD) are less common. Granuloma formation is reported in 34.7%. In Korea, Two reports of MTX pneumonitis have been published. The one presented with NSIP and the other with DAD. We recently experienced a case of MTX pneumonitis with presentation of hypersensitivity pneumonitis.
