Chemo-radiation Therapy for Locally Advanced Non-Small Cell Lung Cancer.
- Author:
Young Taek OH
1
;
Mison CHUN
;
Jin Hyuk CHOI
;
Ho Yeong LIM
;
Seunghee KANG
Author Information
1. Department of Radiation Oncology, Ajou University. School of Medicine, Suwon, Korea. ohyoung@madang.ajou.ac.kr
- Publication Type:Original Article
- Keywords:
NSCLC;
CCRT;
Unresectable
- MeSH:
Carcinoma, Non-Small-Cell Lung*;
Drug Therapy;
Humans;
Induction Chemotherapy;
Weight Loss
- From:Journal of Lung Cancer
2002;1(1):29-33
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Chemotherapy, followed by radiation therapy, improves the survival of patients with locally advanced non-small cell lung cancer (NSCLC). However, it is not clear whether chemotherapy, followed by concurrent chemo-radiation therapy, can improve survivals compared to only concurrent chemo-radiation therapy. We conducted this study to evaluate the role played by induction chemotherapy followed by concurrent chemo-radiation therapy. MATERIALS AND METHODS: Between 1995 and 2000, 55 patients with locally advanced NSCLC were treated with concurrent chemo-radiation therapy. Twenty-seven patients received the induction chemotherapy prior to the chemo-radiation therapy, and their characteristics and survival compared. RESULTS: There were no significant differences in patient characteristics, with the exception of weight loss. The group receiving the induction chemotherapy showed a lesser weight loss, but with no statistical difference in the survival results. CONCLUSION: No advantage was shown with the induction chemotherapy when followed by concurrent chemo-radiation therapy in the treatment of locally advanced NSCLC.
