A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus.
- Author:
Soon Hwa YOON
1
;
Myoung Hoon SONG
;
Seon Hee SHIN
;
Sung Koo KIM
;
Kon Hee LEE
;
Hae Sun YOON
;
Young Ok JUNG
;
Hye Kyung AHN
Author Information
1. Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea. ysh1027@orgio.net
- Publication Type:Case Report
- Keywords:
Kikuchi-Fujimoto disease;
Histiocytic necrotizing lymphadenitis;
Systemic lupus erythematosus
- MeSH:
Antibodies, Antinuclear;
Diagnosis;
Exanthema;
Female;
Histiocytic Necrotizing Lymphadenitis*;
Humans;
Lupus Erythematosus, Systemic;
Lymph Nodes;
Lymphatic Diseases
- From:Korean Journal of Pediatrics
2004;47(8):904-907
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi's disease by lymph node histology, who subsequently developed SLE with constitutional symptoms, skin rash, hematologic and immunologic disorder and high titer of antinuclear antibody. This raises consideration for the proposal that KFD may reflect a SLE-like auto-immune condition. Patients with KFD should be kept under observation for several years for the development of SLE. And KFD should be ruled out in SLE flare-up accompanied by lymphadenopathy.
