The Effect of Splenectomy on Acute Barium Sulfate Induced Toxicity of Rat Organs.
- Author:
Hae Joung SUL
1
;
Dae Young KANG
Author Information
1. Department of Pathology, College of Medicine, Konyang Unversity, Korea. dykang@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Barium Sulfate;
Spleen;
Splenectomy
- MeSH:
Animals;
Barium Sulfate*;
Barium*;
Humans;
Leukocyte Count;
Male;
Rats*;
Spleen;
Splenectomy*
- From:Korean Journal of Pathology
2004;38(4):249-257
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to elucidate whether or not splenectomy alters the acute toxic effects on rat tissue induced by barium sulfate. METHODS: A total of 80 Sprague-Dawely male rats were divided into three groups; the control group and the barium sulfate treated groups with and without splenectomy. The pathologic changes in the solid organs were examined at the time after intraperitoneal treatment with barium sulfate. The changes of white blood cell count were also examined. RESULTS: The barium induced toxicity was most prominent in the spleen. The changes in the other organs were proportional to the experimental duration, and the changes in the barium only treatment group were more severe than the observed changes in the splenectomy and barium treated group. CONCLUSIONS: These results suggest that the degree of barium toxicity of barium only treated group was more severe than that of the splenectomy group.
