Validation of Radiation Volume by Analysis of Recurrence Pattern in Breast-conserving Treatment for Early Breast Cancer.
10.4048/jbc.2009.12.4.257
- Author:
Su Jung SHIM
1
;
Yong Bae KIM
;
Ki Chang KEUM
;
Ik Jae LEE
;
Hy De LEE
;
Chang Ok SUH
Author Information
1. Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul, Korea. cosuh317@yuhs.ac
- Publication Type:Original Article
- Keywords:
Breast conserving surgery;
Radiotherapy;
Recurrence
- MeSH:
Breast;
Breast Neoplasms;
Follow-Up Studies;
Humans;
Lymph Nodes;
Mastectomy, Segmental;
Recurrence;
Retrospective Studies;
Survival Rate
- From:Journal of Breast Cancer
2009;12(4):257-264
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To assess the appropriateness of radiotherapy volume for patients receiving breast-conserving treatment (BCT) through analysis of recurrence pattern and factors affecting recurrence. METHODS: From 1991 to 1996, 362 patients who received BCT were retrospectively evaluated. The radiation volume was the involved breast alone in the patients with less than 4 positive axillary lymph nodes (LNs), and breast and supraclavicular fossa in patients with 4 or more positive axillary LNs. The median follow-up period was 123 months (range, 3-169 months). RESULTS: Ten-year overall, disease-free, local recurrence-free, and regional recurrence-free survival rates were 86.2%, 82.2%, 95.9%, and 95.2%, respectively. Among 310 patients receiving radiotherapy on the breast alone, 15 (4.8%) had regional recurrence. In particular, patients with inner quadrant lesions had high regional recurrence rates (11/98, 11.2%) (p<0.001). CONCLUSION: These low local recurrence rates may reveal that the current radiotherapy technique was successful. However, in cases of inner quadrant lesions, there were a considerable number of regional recurrences, even in N0 cases. This may suggest a potential role for irradiation on regional LNs in this group.
