Altered Biodistribution of Gallium-67 in a Patient with Multiple Factors Influencing Iron-transport Protein Saturation.
- Author:
Byung Tae KIM
;
Sang Eun KIM
;
Kyung Han LEE
;
Joon Young CHOI
- Publication Type:Original Article
- Keywords:
Gallium-67;
Fulminant hepatitis;
Iron deficiency anemia;
Transfusion
- MeSH:
Anemia, Iron-Deficiency;
Female;
Follow-Up Studies;
Hepatitis;
Humans;
Iron-Binding Proteins;
Kidney;
Liver;
Skeleton;
Transferrin
- From:Korean Journal of Nuclear Medicine
1998;32(1):114-119
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We present a case of a young female patient with fulminant hepatitis who showed an altered biodistribution of Ga-67, after being scanned twice at 10 month intevals. On initial scan, uptake of Ga-67 was increased in the liver, kidneys, and skeletons. Increased hepatic Ga-67 uptake may be explained by increased transferrin unbound Ga-67 that was taken up by the inflamed liver. The saturation of iron-binding proteins due to multiple transfusions may lead to increased renal and skeletal Ga-67 uptake. On follow-up scan hepatic Ga-67 uptake was markedly increased. Also increased Ga-67 uptake in the axial skeleton and normalized renal uptake were shown. The findings were consistent with iron deficiency anemia. This case demonstrates altered Ga-67 biodistribution associated with multiple transfusions, fulminant hepatitis, and iron deficiency anemia.
