Transgenesis for pig models.
10.4142/jvs.2016.17.3.261
- Author:
Soo Young YUM
1
;
Ki Young YOON
;
Choong Il LEE
;
Byeong Chun LEE
;
Goo JANG
Author Information
1. Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul 08826, Korea. snujang@snu.ac.kr
- Publication Type:Review
- Keywords:
conditional expression;
knockout;
genome editing;
pig;
transgenesis
- MeSH:
Animals;
Gene Expression;
Gene Transfer Techniques*;
Mice;
Models, Animal;
Recombinases;
Swine
- From:Journal of Veterinary Science
2016;17(3):261-268
- CountryRepublic of Korea
- Language:English
-
Abstract:
Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expression like mice has been raised. Currently, advanced genome-editing technologies enable us to generate specific gene-deleted and -inserted pig models. In the future, the development of pig models with gene editing technologies could be a valuable resource for biomedical research.
