Effects of Chemical Sympathectomy in the Causalgiform Pain Produced by Unilateral Partial Ligation of Sciatic Nerve in Rats.
10.4097/kjae.1992.25.6.1037
- Author:
Won Hyung LEE
1
;
Neung Hyi HAN
;
Kwang Jin KIM
Author Information
1. Department of Anesthesiology, College of Medicine, Chungnam National University, Korea.
- Publication Type:Original Article
- Keywords:
Causalgia;
Heat hyperalgesia;
Mechanical allodynia;
Chemical sympathectomy;
Guanethidine
- MeSH:
Animals;
Causalgia;
Guanethidine;
Hot Temperature;
Hyperalgesia;
Ligation*;
Rats*;
Sciatic Nerve*;
Sympathectomy;
Sympathectomy, Chemical*
- From:Korean Journal of Anesthesiology
1992;25(6):1037-1047
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We produced the cauaalgiform pain by unilateral 1/3-1/2 ligation of sciatic nerve in rats.. Withdrawal thresholds to non-noxious stimulation were reduced(mechanical allodynia), and withdrawal thresholds to heat stimulation were reduced(heat hyperalgesia) too. After that, we injected 50 mg/kg guanethidine intraperitoneally for the study of the effects of chemical sympathectomy in postopertive 7th day, 37th day respectively. The results were as follows 1) Mechanical allodynia was alleviated partially in 12 hours, first day after sympathectomy. 2) Heat hypera1gesia was alleviated completely in first day to 4th day after sympathectomy, and reappeared after 5th day.
