Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy.
10.3346/jkms.2013.28.11.1697
- Author:
Young Hee NAM
1
;
Eui Kyung HWANG
;
Hyun Jung JIN
;
Jeong Min LEE
;
Yoo Seob SHIN
;
Young Min YE
;
Arantxa PALACIN
;
Gabriel SALCEDO
;
Soo Young LEE
;
Hae Sim PARK
Author Information
1. Department of Internal Medicine, Dong-A University School of Medicine, Busan, Korea.
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Baker's Asthma;
Gliadin;
Lipid Transfer Protein;
Wheat
- MeSH:
Adult;
Anaphylaxis/immunology;
Antigens, Plant/*immunology;
Asthma/blood/diagnosis/immunology;
Biological Markers/blood;
Carrier Proteins/*immunology;
Female;
Gliadin/*immunology;
Humans;
Immunoglobulin E/*blood/immunology;
Male;
Phenotype;
Triticum/immunology;
Urticaria/immunology;
Wheat Hypersensitivity/*diagnosis/*immunology
- From:Journal of Korean Medical Science
2013;28(11):1697-1699
- CountryRepublic of Korea
- Language:English
-
Abstract:
Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical densityx1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.
