Increased Vascular Endothelial Growth Factors in Nasopharyngeal Aspirates from Children with Acute RSV Bronchiolitis.
- Author:
Kyong Suk LA
1
;
Hyo Kyoung NAM
;
Siegfried BAUER
;
Ji Eun KIM
;
Ic Sun CHOI
;
Yoon LEE
;
Young YOO
;
Sang Hee PARK
;
Ji Tae CHOUNG
Author Information
1. Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea. yoolina@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Bronchiolitis;
Children;
RSV;
Vascular endothelial growth factor;
Wheezing
- MeSH:
Bronchiolitis;
Capillary Permeability;
Child;
Enzyme-Linked Immunosorbent Assay;
Humans;
Korea;
Physical Examination;
Respiratory Sounds;
Respiratory Syncytial Viruses;
Risk Factors;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factors
- From:Pediatric Allergy and Respiratory Disease
2010;20(3):166-172
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Viral infection is known as one of the dominant risk factors for wheezing in children hospitalized before 2 years of age. Although the major viral pathogen associated with wheezing is respiratory syncytial virus (RSV), the mechanisms of wheezing remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability. The aim of this study was to evaluate the relationship between VEGF concentration and wheezing in children with acute RSV bronchiolitis. METHODS: Ninety-four children with acute bronchiolitis who were admitted to Korea University Anam Hospital were enrolled in this study. Based on the proven viral agents, children with bronchiolitis were divided into 2 groups: those who were infected with RSV (RSV (+) group, n=51) and those who were not (RSV (-) group, n=43). A complete history taking, physical examination and routine laboratory tests were performed on all children. VEGF levels in serum and nasopharyngeal aspirates (NPA) were determined by ELISA. RESULTS: NPA VEGF levels were significantly higher in the RSV (+) group than in the RSV (-) group (331.8+/-197.8 vs. 204.5+/-97.0 pg/mL, P=0.002). The duration of wheezing is significantly longer in the RSV (+) group than in the RSV (-) group (3.8+/-2.7 days vs. 2.4+/-1.8 days, P=0.037). CONCLUSION: The results of this study suggest that children with RSV bronchiolitis may have significantly higher NPA VEGF levels than those without, which may be associated with a longer duration of wheezing in those with RSV bronchiolitis.
