Effects of an Extract from Cimicifuga racemosa in Menopausal Women.
- Author:
Jin Wan PARK
1
;
Eui Jong HUR
;
Won Ki LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Dan Kook University, Cheonan, Korea.
- Publication Type:Original Article ; Comparative Study ; Randomized Controlled Trial
- Keywords:
Menopause;
Cimicifuga racemosa;
hormone replacement therapy
- MeSH:
Cimicifuga*;
Densitometry;
Estrogen Replacement Therapy;
Estrogens;
Female;
Hormone Replacement Therapy;
Humans;
Medroxyprogesterone Acetate;
Menopause
- From:Korean Journal of Obstetrics and Gynecology
2002;45(1):117-121
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of the study is to assess the effects of treatment with an extract from Cimicifuga racemosa for 1 year in postmenopausal women with symptoms. METHODS: In a randomised, open-label, group-comparative study, the change on the Kupperman menopausal index, serum FSH and E2 level, bone densitometry (BMD), and mammographic density by an extract from Cimicifuga racemosa (GYNO-Qx ) (N=40) were compared with an conjugated equine estrogen combined with medroxyprogesterone acetate (CEE/MPA) (N=36) during 12 months in menopausal women. RESULTS: There were no statistical differences in the change of Kupperman index, serum FSH and E2 level, and mammographic density between two groups after 12 months, except the effect of BMD that the CEE/MPA group (+6.6%) was significantly increased as compared to the extract from Cimicifuga racemosa (+1.1%) baseline. CONCLUSION: This study suggests that an extract of Cimicifuga racemosa is a safe, effective alternative to estrogen replacement therapy for patients in whom hormone replacement therapy is either refused or contraindicated.
