Association of Vitamin D Status with Acute Lower Respiratory Infection in Children.
- Author:
Young Jae KIM
1
;
Ju Seok LEE
Author Information
1. Department of Laboratory medicine, Sungkyunkwan University, School of Medicine, Samsung Changwon Hospital, Changwon, Korea.
- Publication Type:Original Article
- Keywords:
Vitamin D;
Pneumonia;
Bronchiolitis
- MeSH:
Bronchiolitis;
Child;
Hospitalization;
Humans;
Immunoassay;
Micronutrients;
Pneumonia;
Prevalence;
Respiratory Tract Infections;
Vitamin D;
Vitamins
- From:Pediatric Allergy and Respiratory Disease
2010;20(3):173-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Acute lower respiratory tract infection (ALRI) is a common disease in children. Micronutrient deficiencies may increase the risk of ALRI. The aim of this study is to determine the association of vitamin D status with susceptibility to ALRI by comparing serum 25 hydroxy-vitamin D [25(OH)D] levels between a group of young children under 5 years of age with ALRI and healthy children. METHODS: Serum 25(OH)D concentrations were measured in patients under 5 years of age admitted to hospital with a diagnosis of pneumonia (n=40) or bronchiolitis (n=34) from October 2009 to December 2009 as well as in healthy patients of similar age without respiratory symptoms (n=54). Serum 25(OH)D concentrations were measured by electrochemileuminescence immunoassay. RESULTS: The mean serum 25(OH)D level were similar between the ALRI and control groups (28.4+/-9.0 versus 29.1+/-7.1 ng/mL). There was no significant difference in the prevalence of 25(OH)D insufficiency between the 2 groups at 2 thresholds (for <15 ng/mL, 8.1 vs. 5.6%; P=0.19, and for <30 ng/mL, 59.5 vs. 64.8%; P=0.75). CONCLUSION: In our study, no difference was observed in vitamin D levels between the ALRI and control groups. Therefore, Vitamin D status may not be associated with the risk of hospitalization for ALRI in children.
