Bilateral Triple-Negative Invasive Breast Cancer with a BRCA2 Mutation, and Glioblastoma: A Case Report and Literature Review.
10.4048/jbc.2017.20.1.108
- Author:
Ali RAUFI
1
;
Mohamed ALSHAREDI
;
Yousef KHELFA
;
Maria TIRONA
Author Information
1. Division of Hematology-Oncology, Department of Medicine, Joan C. Edwards School of Medicine at Marshall University/Edward Comprehensive Care Center, Huntington, USA. raufi@marshall.edu
- Publication Type:Case Report
- Keywords:
BRCA2 genes;
Glioblastoma;
Triple-negative breast neoplasms
- MeSH:
Adult;
Breast Neoplasms*;
Breast*;
Cause of Death;
Central Nervous System;
Female;
Genes, BRCA2;
Glioblastoma*;
Humans;
Incidence;
North America;
Triple Negative Breast Neoplasms
- From:Journal of Breast Cancer
2017;20(1):108-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
Breast cancer is the second leading cause of death among women in North America. Glioblastoma is the most common primary malignant central nervous system tumor in adults. The majority of hereditary breast cancers are associated with deleterious mutations in the BRCA1 and BRCA2 genes. Although few case reports have described the incidence of glioblastoma in patients previously diagnosed with breast cancer, any association between BRCA2 mutations and glioblastoma has not been demonstrated to date. Herein, we report a woman who is a carrier of a familial BRCA2 mutation, and was previously diagnosed with triple-negative breast cancer (TNBC) and subsequently with a second primary TNBC and glioblastoma. Further investigation is required to define the possible relationship between these two aggressive malignances and the BRCA2 mutation, which might be critical for the proper management and treatment of this disease.
