Impression Cytology Study of Conjunctival Cytotoxicity Caused by Instillation of Low-Dose Mitomycin C.
- Author:
Woo Ho CHANG
1
;
See Soo LIM
;
Jae Woo KIM
Author Information
1. Department of Ophthalmology, School of Medicine Catholic University of Taegu-Hyosung.
- Publication Type:Original Article
- Keywords:
Conjunctival Cytotoxicity;
Glaucoma;
Impression Cytology;
low-dose mitomycin C
- MeSH:
Aged;
Case-Control Studies;
Conjunctiva;
Glaucoma;
Humans;
Mitomycin*;
Ophthalmic Solutions;
Prevalence;
Prospective Studies;
Pterygium
- From:Journal of the Korean Ophthalmological Society
1997;38(6):942-948
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We conducted a prospective case-control study to evaluate the conjunctival cytotoxicity of low-dose mitomycin C instillation by impression cytology which was performed preoperatively, postoperative 1 week and 2 weeks in patients undergoing pterygium excision. The case group consisted of 35 patients with postoperative 0.02% topical mitomycin C for 1 week and the control group consisted of 10 patients without postoperative mitomycin C. Impression cytologic findings were graded to 4 scores. Compared to preoperative values there was stastically significant difference in grading scores at postoperative 1 week and 2 weeks (P=0.001, 0.0026) between the groups. Within the case group, the grading scores after 1 week were significantly higher than preoperative values (P=0.0001), but grading scores a 2 weeks decreased significantly compared to those at 1 week and the prevalence of grade 2 or more was also decreased from 40% to 20%. The patients over 50 years of age showed significantly higher gading scores than the patients below 50 years of age (P=0.0038) up to 2 weeks within the case group. Our results revealed that the conjunctiva could be damaged by lowdose mitomycin C and this damage may be more severe and persist longer in elderly. This study suggests that the possible conjunctival cyotoxicity should be considered when using topical mitomycin C eyedrops in management of glaucoma.
