Retinotoxic Effect of Sodium Iodate in the Rabbit.
- Author:
Dong Hee KIM
1
;
Hyung Woo KWAK
;
Jae Myung KIM
Author Information
1. Department of Ophthalmology, College of Medicine, Kyunghee University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Sodium iodate;
Retinal pigment epithelium;
ERG;
Electron microscopy
- MeSH:
Animals;
Epithelium;
Injections, Intravenous;
Microscopy, Electron;
Rabbits;
Retinal Pigment Epithelium;
Sodium*
- From:Journal of the Korean Ophthalmological Society
1997;38(6):1006-1012
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study is to investigate the minimal toxic dose of sodium iodate after the intravenous injection in the pigmented rabbits. Thirteen rabbits were given a intravenous injection of 2% sodium iodate(pH 7.4). The animals were devided into two groups, the 10mg/kg and 25mg/kginjected groups. In ERG findings, the b wave amplitude decreased one week after injection in both groups and was recovered at 5 weeks in the 10mg/kg-injected group, but it was not recovered upto 5 weeks in the 25mg/kg-injected group. In the electron microscopic findings, the abnormal change was not observed in the 10mg/kg-injected group but the pigment epithelium and outer segments of the photoreceptors were markedly destroyed and did not recovered upon the 5 weeks in the 25mg/kg-injected group. Therefore, ultrastructural and functional changes occurred in a 25mg/kg of sodium iodate injected group and those changes were not recovered for the period of 5 weeks after injection.
