Distribution of HIV-1 Subtypes by Transmission Routes in Korea.
- Author:
Joo Shil LEE
1
;
Jeong Gu NAM
;
Sung Soon KIM
;
Chun KANG
;
Byung Sun CHOI
;
Ok Jin KIM
;
Mi Sun PARK
;
Bong Mo SEONG
;
Soon Duk SUH
;
Soo Kyung JEON
;
Seung Ok BYUN
;
Yung Oh SHIN
;
Hae Wol CHO
Author Information
1. Center for AIDS Research, Department of Virology, National Institute of Health, Korea.
- Publication Type:Original Article
- Keywords:
HIV;
Subtype;
Molecular epidemiology
- MeSH:
DNA;
Female;
Genes, env;
Hand;
Heterosexuality;
HIV;
HIV Infections;
HIV-1*;
Hominidae;
Homosexuality;
Humans;
Korea*;
Male;
Molecular Epidemiology;
Polymerase Chain Reaction;
Spouses
- From:Korean Journal of Infectious Diseases
2001;33(5):311-318
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. METHODS: 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. RESULTS: HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30%:13 A, 4 C, 2 D, 8 E, 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. CONCLUSION: The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea.
