Two Cases of Severe Plasmodium falciparum Malaria Complicated with Acute Respiratory Distress Syndrome.
- Author:
Su Mi CHOI
1
;
Youn Jeong LEE
;
Sun Hee PARK
;
Myoung Beom KOH
;
Sang Il KIM
;
Yang Ree KIM
;
Young Kyoon KIM
;
Moon Won KANG
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Malaria;
Falciparum;
Pulmonary edema;
Acute Respiratory distress syndrome
- MeSH:
Acute Kidney Injury;
Anemia;
Communicable Diseases;
Delayed Diagnosis;
Diuretics;
Doxycycline;
Ghana;
Humans;
Hyperbilirubinemia;
Hypoglycemia;
Lung;
Lung Injury;
Malaria;
Malaria, Cerebral;
Malaria, Falciparum*;
Masks;
Mortality;
Oxygen;
Parasitemia;
Plasmodium falciparum*;
Plasmodium*;
Pulmonary Edema;
Quinine;
Renal Dialysis;
Respiration, Artificial;
Respiratory Distress Syndrome, Adult*;
Thailand;
Thrombocytopenia
- From:Korean Journal of Infectious Diseases
2001;33(5):354-359
- CountryRepublic of Korea
- Language:English
-
Abstract:
Malaria remains one of the most important infectious diseases in the world. For those not immuned to malaria, delayed diagnosis and treatment have been associated with an increase in morbidity and mortality, and development of severe complications. Pulmonary edema is one of the serious complications in falciparum malaria. It usually occurs in association with cerebral malaria, acute renal failure, high parasitemia, and delayed antimalarial treatment, as well as treatment-related side effects. We report two cases of severe falciparum malaria with rapidly developed pulmonary edema, which was not combined with cardiac decompensation or fluid overload. Both patients had a history of traveling to foreign countries, Thailand and Ghana, which chloroquine-resistant malaria is distributed. The first patient who developed hyperbilirubinemia, hypoglycemia, thrombocytopenia, decreased mentality, multi-organ failure, and pulmonary edema with acute respitatory distress syndrome, was treated with quinine, doxycycline, hemodialysis, and mechanical ventilation. The patient was recovered with a sequela of restrictive lung change. The second patient also developed anemia, thrombocytopenia, mental confusion, and pulmonary edema with aucte lung injury. Through the treatment of quinine, diuretics, and high concentration of oxygen via facial mask, the patient was successfully recovered without any sequela.
