Warfarin-induced Skin Necrosis After Valve Surgery.
- Author:
Seung Chul MOON
1
;
Kun LEE
;
Hun Jae LEE
;
Dae Ho AHN
;
Chang Young LIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Heart Center, Pundang CHA General Hospital, Pochon CHA University.
- Publication Type:Original Article
- Keywords:
Warfarin;
Complication;
Necrosis;
heart valve replacement
- MeSH:
Breast;
Heparin;
Heparin, Low-Molecular-Weight;
Humans;
Molecular Weight;
Necrosis*;
Protein C;
Prothrombin;
Skin*;
Warfarin
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1999;32(3):307-309
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Warfarin-induced skin necrosis is a rare complication caused by transient hypercoagulable state. This state is a result of rapid decline of the protein C activity relative to that of coagulation factor II, IX, and X during initiation of oral anticoagulant therapy. We experienced a case of warfarin-induced skin necrosis involving both breasts in a patient who underwent double valve replacement 1 month before. Warfarin was replaced to a low- molecular weight heparin and the necrotic breast lesion was healed spontaneously. Low-dose warfarin was restarted and gradually increased, after which a low molecular weight heparin discontinued.
