Protease Inhibitor Treatment of Disseminated Intravascular Coagulation Associated with Aortic Dissection.
- Author:
Sung Min KO
1
;
Namjun KIM
;
Chunghun KIM
;
Jin Hyun CHO
;
Eun Young LEE
;
Kyungmin HUH
;
Duk Kyung KIM
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dukkyung.kim@samsung.com
- Publication Type:Case Report
- Keywords:
Aortic dissection;
Disseminated intravascular coagulation;
Protease inhibitor;
Nafamostat mesilate;
Heparin
- MeSH:
Aneurysm;
Aorta;
Dacarbazine;
Disease Susceptibility;
Disseminated Intravascular Coagulation;
Ecchymosis;
Female;
Fibrin Fibrinogen Degradation Products;
Guanidines;
Hemorrhage;
Heparin;
Humans;
Intracranial Hemorrhages;
Middle Aged;
Protease Inhibitors;
Thrombocytopenia
- From:Korean Journal of Medicine
2012;82(3):341-346
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Disseminated intravascular coagulation (DIC) is a rare complication of aortic dissection. We report an unusual case of a 64-year-old woman with DIC associated with chronic aortic dissection who developed catastrophic intracranial hemorrhage. Computed tomography (CT) revealed partially thrombosed false lumen in the chronic dissected aneurysm of the thoracoabdominal aorta, which remained after surgery for acute type A aortic dissection. The laboratory profile showed features of DIC, including thrombocytopenia, hypofibrinogenemia, and increased D-dimer levels. Bleeding diathesis, including ecchymosis and coagulopathy, showed improvement following treatment with protease inhibitors (nafamostat and camostat).
