A Case of Linezolid-Associated Lactic Acidosis.
- Author:
Hong Joo LEE
1
;
Jae Ho CHOI
;
Sun Yong KIM
;
Kyung Hwan CHUNG
;
Tae Won LEE
;
Chun Gyoo IHM
;
Ju Young MOON
Author Information
1. Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea. kidmjy@hanmail.net
- Publication Type:Case Report
- Keywords:
Linezolid;
Lactic acidosis
- MeSH:
Acetamides;
Acidosis, Lactic;
Aged;
Cross Infection;
Enterococcus faecium;
Female;
Humans;
Metformin;
Methicillin Resistance;
Methicillin-Resistant Staphylococcus aureus;
Oxazolidinones;
Pneumonia;
Renal Dialysis;
Skin;
Staphylococcus;
Staphylococcus aureus;
Streptococcus pneumoniae;
Wound Infection;
Linezolid
- From:Korean Journal of Medicine
2012;82(3):371-373
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Linezolid has been used for treatment of vancomycin-resistant Enterococcus faecium infection, nosocomial pneumonia caused by Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus or Streptococcus pneumoniae, and complicated and uncomplicated skin and skin structure infections. Lactic acidosis is an adverse effect associated with drugs, including metformin, the nucleoside reverse-transcriptase inhibitors and, rarely, linezolid. We report a case in which severe lactic acidosis developed as an adverse effect of linezolid in a 75-year-old woman who had been on linezolid for 30 days for treatment of a wound infection caused by methicillin-resistant coagulase-negative Staphylococcus. Discontinuation of linezolid and hemodialysis improved her lactic acidosis.
