Validity of Glycated Hemoglobin in Screening and Diagnosing Type 2 Diabetes Mellitus in Chinese Subjects.
10.3904/kjim.2012.27.1.41
- Author:
Yun YU
1
;
Xiao Jun OUYANG
;
Qing Lin LOU
;
Liu Bao GU
;
Yong Zhen MO
;
Gary T KO
;
Chun Chung CHOW
;
Wing Yee SO
;
Ronald MA
;
Alice KONG
;
Nicola BROWN
;
Jennifer NAN
;
Juliana CHAN
;
Rong Wen BIAN
Author Information
1. Diabetes Care and Research Center, Jiangsu Province Institute of Geriatrics, Nanjing, China.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't ; Validation Studies
- Keywords:
Glycated hemoglobin;
Glucose tolerance test;
Diagnosis;
Diabetes mellitus, type 2
- MeSH:
Aged;
Analysis of Variance;
*Asian Continental Ancestry Group;
Biological Markers/blood;
Blood Glucose/analysis;
China/epidemiology;
*Chromatography, High Pressure Liquid/standards;
*Chromatography, Ion Exchange/standards;
Diabetes Mellitus, Type 2/blood/*diagnosis/ethnology;
Fasting/blood;
Female;
Glucose Tolerance Test/standards;
Hemoglobin A, Glycosylated/*analysis;
Humans;
Male;
Mass Screening/*methods/standards;
Middle Aged;
Predictive Value of Tests;
ROC Curve;
Reference Standards;
Reproducibility of Results;
Sensitivity and Specificity
- From:The Korean Journal of Internal Medicine
2012;27(1):41-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The application of glycated hemoglobin (HbA1c) for the diagnosis of diabetes is currently under extensive discussion. In this study, we explored the validity of using HbA1c as a screening and diagnostic test in Chinese subjects recruited in Nanjing, China. METHODS: In total, 497 subjects (361 men and 136 women) with fasting plasma glucose (PG) > or = 5.6 mmol/L were recruited to undergo the oral glucose tolerance test (OGTT) and HbA1c test. Plasma lipid, uric acid, and blood pressure were also measured. RESULTS: Using a receiver operating characteristic curve, the optimal cutoff point of HbA1c related to diabetes diagnosed by the OGTT was 6.3%, with a sensitivity and specificity of 79.6% and 82.2%, respectively, and the area under the curve was 0.87 (95% confidence interval, 0.83 to 0.92). A HbA1c level of 6.5% had a sensitivity and specificity of 62.7% and 93.5%, respectively. When comparing the HbA1c > or = 6.5% or OGTT methods for diagnosing diabetes, the former group had significantly higher HbA1c levels and lower levels of fasting and 2-hour PG than the latter group. No significant difference was observed in the other metabolism indexes between the two groups. CONCLUSIONS: Our results suggest that HbA1c > or = 6.5% has reasonably good specificity for diagnosing diabetes in Chinese subjects, which is in concordance with the American Diabetes Association recommendations.
