An Insertion/Deletion Polymorphism in the alpha(2B)-Adrenoceptor Gene is not a Genetic Risk Factor for Coronary Artery Disease in the Korean Population.
10.4070/kcj.2005.35.3.215
- Author:
Jung Ran CHOI
1
;
Chan Mi PARK
;
Jeong Ae HONG
;
Soo Jin BAE
;
Sang Mi EOM
;
Eun Young CHO
;
Young Guk KO
;
Hyun Young PARK
;
Yang Soo JANG
Author Information
1. BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. jangys1212@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary artery disease;
alpha(2B)-adrenoceptors;
Polymorphism, genetic
- MeSH:
Cardiovascular Diseases;
Coronary Artery Disease*;
Coronary Vessels*;
Female;
Genome;
Genotype;
Humans;
Male;
Polymorphism, Genetic;
Risk Factors*
- From:Korean Circulation Journal
2005;35(3):215-220
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Cardiovascular disease (CVD) is a complex multigenic disorder, with significant inheritable elements having important roles relating to environmental factors. Recently, the alpha 2 adrenoceptor (alpha(2)-AR) gene has been reported to be involved in the development of coronary artery disease (CAD). The aim of this study was to investigate the relationships between an insertion/deletion (I/D) in alpha(2B)-AR and CAD in Korean subjects. SUBJECTS AND METHODS: The alpha(2B)-AR I/D polymorphism, which was located in the third intracellular loop of the receptor polypeptide, was examined in 292 patients (M:F=219:73) with CAD and 151 healthy control subjects (M:F=70:81) who visited the Cardiovascular Genome Center in Yonsei Cardiovascular Hospital. RESULTS: In the patient group, 77 men (35.1%) and 26 women (35.6%) had the I/I genotype; 105 men (47.9%) and 39 women (53.4%) a heterozygous genotype and 37 (17.0%) and 8 (11.0%) the D/D genotype. In the controls, 23 men (32.8%) and 29 women (35.8%) had the I/I genotype; 38 (54.3%) and 39 (48.1%) the I/D genotype and 9 (12.9%) and 13 (16.1%) the D/D genotype. There were no differences in the genotype frequencies between the patient and control groups, either in men or women. From a logistical regression analysis, the alpha(2B)-AR genotype was not significantly associated with CAD in our study group. CONCLUSION: The alpha(2B)-AR I/D polymorphism is not a risk factor for CAD in the Korean population.
