The Significance of the Lymphatic Micro Vessel Density and Vascular Endothelial Growth Factor- C Expression for Colorectal Cancer.
- Author:
Tae Hee KIM
1
;
Yong Sok KIM
;
Young Chol CHOI
;
Bom Ku KIM
;
Tae Jin LEE
;
Yong Geum PARK
Author Information
1. Department of Surgery, College of Medicine, Chung-Ang University, Seoul, Korea. torog@hanmail.net
- Publication Type:Original Article
- Keywords:
Colorectral cancer;
VEGF-C;
D2-40;
Lymphatic microvessel density
- MeSH:
Chemotherapy, Adjuvant;
Colonic Neoplasms;
Colorectal Neoplasms*;
Humans;
Lymph Nodes;
Lymphatic Vessels;
Neoplasm Metastasis;
Neoplastic Cells, Circulating;
Prognosis;
Vascular Endothelial Growth Factor C
- From:Journal of the Korean Surgical Society
2007;73(5):406-411
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Studying the prognostic factors of distant metastasis is quite important for predicting these patients' prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors. METHODS: 79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate. RESULTS: The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the T- stage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer. CONCLUSION: The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer.
