QT Prolongation and Life Threatening Ventricular Tachycardia in a Patient Injected With Intravenous Meperidine (Demerol(R)).
10.4070/kcj.2011.41.6.342
- Author:
Mi Kyoung SONG
1
;
Eun Jung BAE
;
Jae Suk BAEK
;
Bo Sang KWON
;
Gi Beom KIM
;
Chung Il NOH
;
Jung Yun CHOI
;
Sung Sup PARK
Author Information
1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea. eunjbaek@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Long QT syndrome;
Meperidine;
Torsade de pointes
- MeSH:
Adolescent;
Death, Sudden;
Heart Diseases;
Humans;
Long QT Syndrome;
Meperidine;
Polymorphism, Single Nucleotide;
Tachycardia, Ventricular;
Torsades de Pointes;
Ventricular Fibrillation
- From:Korean Circulation Journal
2011;41(6):342-345
- CountryRepublic of Korea
- Language:English
-
Abstract:
QT prolongation is a serious adverse drug effect, which is associated with an increased risk of Torsade de pointes and sudden death. Many drugs, including both cardiac and non-cardiac drugs, have been reported to cause prolongation of QT interval. Although meperidine has not been considered proarrhythmic, we present a unique case of a 16-year-old boy without an underlying cardiac disease, who developed polymorphic ventricular tachycardia, ventricular fibrillation and QT prolongation after an intravenous meperidine injection. He had no mutation in long QT syndrome genes (KCNQ1, KCNH2, and SCN5A), but single nucleotide polymorphisms were reported, including H558R in SCNA5A and K897T in KCNH2.
