Comparison of bare metal stent and paclitaxel-eluting stent using a novel rat aorta stent model.
10.4142/jvs.2011.12.2.143
- Author:
Jin Sook KWON
1
;
Rho Kwan PARK
;
Tae Jin SHIM
;
Myung Ho JEONG
;
Myeong Chan CHO
;
Youngkeun AHN
;
Dong Woon KIM
Author Information
1. Department of Cardiology, Chonnam National University Hospital, Gwanju 501-757, Korea. cecilyk@chonnam.ac.kr
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
aorta;
neointimal hyperplasia;
rat;
re-endothelialization;
stents
- MeSH:
Angioplasty/*methods;
Animals;
Aorta, Thoracic/*surgery/ultrastructure;
Coronary Artery Disease/*surgery;
*Drug-Eluting Stents;
Histocytochemistry;
Male;
Microscopy, Electron, Scanning;
Models, Animal;
Neointima/pathology;
Paclitaxel/*administration & dosage;
Rats;
Rats, Sprague-Dawley
- From:Journal of Veterinary Science
2011;12(2):143-149
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of our study was to create a novel rat aorta stent implantation model. Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 +/- 20 g). Two and four weeks after stent implantation, the aorta were collected, fixed with 2% glutaraldehyde, and cut into two segments. One segment was used for scanning electron microscopy analysis to evaluate re-endothelialization, and the other segment was used to calculate the neointimal area. At 2 weeks after stenting, the appearance of neointimal hyperplasia was less in the PES group than in the BMS group. At 4 weeks after stenting, no significant difference in neointimal hyperplasia was observed between two groups. On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group. This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.
