Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-(L)-Methionine.
10.4062/biomolther.2016.254
- Author:
Ki Taek KIM
1
;
Ji Su KIM
;
Min Hwan KIM
;
Ju Hwan PARK
;
Jae Young LEE
;
WooIn LEE
;
Kyung Kuk MIN
;
Min Gyu SONG
;
Choon Young CHOI
;
Won Serk KIM
;
Hee Kyung OH
;
Dae Duk KIM
Author Information
1. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea. ddkim@snu.ac.kr
- Publication Type:Original Article
- Keywords:
S-methyl-(L)-methionine;
Vitamin U;
Skin permeation;
Deposition;
Enhancers
- MeSH:
Animals;
Ethanol;
In Vitro Techniques*;
Mice;
Mice, Hairless;
Oleic Acid;
Skin Care;
Skin*;
Vitamin U;
Wound Healing
- From:Biomolecules & Therapeutics
2017;25(4):434-440
- CountryRepublic of Korea
- Language:English
-
Abstract:
S-methyl-(L)-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of −3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the in vitro skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect. Moreover, the combination of oleic acid and ethanol further enhanced in vitro permeation and deposition of SMM through hairless mouse skin. Furthermore, the combination of oleic acid and ethanol significantly increased the in vivo deposition of SMM in the epidermis/dermis for 12 hr, which was high enough to exert a therapeutic effect. Therefore, based on the in vitro and in vivo studies, the combination of oleic acid and ethanol was shown to be effective in improving the topical skin delivery of SMM, which may be applied in the cosmetic production process for SMM.
