A Case of Hemolysis in ABO-unmatched Liver Transplantation: Use of Washed Group O Red Blood Cells and Steroids.
- Author:
Si Hyun BAE
1
;
Jeong Won JANG
;
Min Soo KIM
;
Hyun Jong OH
;
Jong Young CHOI
;
Nam Ik HAN
;
Seung Kew YOON
;
Joon Yeol HAN
;
Eun Jee OH
;
Dong Gu KIM
Author Information
1. Departments of Internal Medicine, Kangnam St. Marys Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. yoonsk@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Liver transplantation;
ABO blood-group system;
Hemolytic anemia;
Steroids
- MeSH:
*ABO Blood-Group System;
Adult;
Anemia, Hemolytic/*etiology/therapy;
Blood Group Incompatibility/*complications;
Erythrocyte Transfusion/adverse effects;
Glucocorticoids/*administration & dosage;
Humans;
*Liver Transplantation;
Male;
Prednisolone/*administration & dosage
- From:The Korean Journal of Gastroenterology
2005;45(5):369-373
- CountryRepublic of Korea
- Language:English
-
Abstract:
Liver transplantation is the only curative therapy for patients with end-stage liver disease. The high success rate and the increasing demand for the transplantation sometimes calls for ABO-compatible but nonidentical blood group orthotopic liver transplantation (OLT), which affords the opportunity to the production of antibody to red blood cells. Hemolytic anemia usually occurs 1 to 2 weeks after transplantation. Although mild in most patients, it can be life-threatening. Until now, a few cases showing hemolytic anemia due to donor ABO antibody formation after ABO-nonidentical OLT have been reported. In the reported cases of hemolytic anemia, most ABO-nonidentical OLT cases were O-to-A, but few reports are available on this subject with O-to-B ABO- nonidentical OLT. Herein, we report the experience with hemolysis after ABO-nonidentical OLT in a group O donor into a group B recipient and the successful treatment with transfusion of washed group O red blood cells and 60 mg dose of prednisolone for 3 days.
