Clinical and Histopathological Study of Calcinosis Cutis.
- Author:
Ho Sun JANG
;
Moon Bum KIM
;
Chang Keun OH
;
Kyung Sool KWON
;
Jang Soo LEE
- Publication Type:Original Article
- Keywords:
Clinical and histopathological study;
Calcinosis cutis
- MeSH:
Calcinosis*;
Calcium;
Carcinoma, Basal Cell;
Carcinoma, Squamous Cell;
Connective Tissue;
Dermatomyositis;
Elastic Tissue;
Epidermal Cyst;
Female;
Foreign Bodies;
Foreign-Body Reaction;
Giant Cells;
Humans;
Incidence;
Pilomatrixoma;
Pseudoxanthoma Elasticum;
Skin Diseases
- From:Korean Journal of Dermatology
1999;37(2):141-149
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Calcinosis cutis may occur when connective tissue is abnormal (dystrophic), or where calcium or phosphate levels in the blood are high(metastatic); alternatively, there may be no obvious underlying cause(idiopathic). The exact incidence of calcinosis cutis in dermatologic patients is not well-kniown and the pathomechanism of it remains to be elucidated. OBJECTIVE: This study was performed to analyze the incidence, clinical and histopathological features of calcinosis cutis. METHODS: We studied 72 patients with calcinosis cutis who visited our department between January 1985 and December 1996. The patients were classified into 3 types (dystrophic, metastatic, and idiopathic) and were analyzed clinically and histopathologically. Results : The results were summerized as follows; 1. There were 60 cases(83.3%) and 12 cases(16.7%) of the dystrophic and idiopathic types, respectively but the metastatic type was not observed. The frequency of dystrophic calcification in individual disorders was 88.2% in pseudoxanthoma elasticum, 66.7% in trichilemmal cyst and dermatomyositis, and 64.6% in pilomatrichoma. 2. In the idiopathic type, it was common in females aged over 50 years and the mean duration of lesions was 2.8+/-2.0 years. The predilection site was the flank(5 cases) and most of the lesions(7 cases) showed skin-colored nodules 3. Histopathologically, calcified material of the idiopathic type was located predominently in the dermis(10 cases) and was present as large masses surrounded by a foreign body reaction. 4. In the dystrophic type, calcified deposits were noted predominently within the shadow cells of pilomatricoma, in the degenerated elastic fibers of pseudoxanthoma elasticum, and in the keratinized area of basal cell carcinoma, squamous cell carcinoma, trichilemmal cyst, and epidermal cyst. Foreign body reactions with giant cells and mononuclear cell infiltrations were often found around large deposits of calcium. Conclusion : The incidence of calcinosis cutis in dermatologic patients is relatively low, but a variety of disorders can be associated with cutaneous calcification. Therefore, dermatologists should be familiar with the different forms of cutaneous calcification and the dermatoses that manifest them.
