A Case of Primary Anti-D Alloimmunization by RHD (c.1227G>A) DEL Red Blood Cell Transfusion.
10.17945/kjbt.2016.27.2.169
- Author:
Jung YOON
1
;
Young Eun KOH
;
Ha Nui KIM
;
Jeeyong KIM
;
Bo Kyeung JUNG
;
Sun Ah LEE
;
Deok Ja OH
;
Chae Seung LIM
Author Information
1. Department of Laboratory Medicine, Korea University Guro Hospital, Seoul, Korea. malarim@korea.ac.kr
- Publication Type:Case Report
- Keywords:
RHD genotyping;
DEL;
Anti-D antibody;
Transfusion
- MeSH:
Erythrocyte Transfusion*;
Erythrocytes*;
Humans;
Immunization;
Infant, Newborn;
Korea;
Phenotype;
Transfusion Reaction
- From:Korean Journal of Blood Transfusion
2016;27(2):169-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The Rh blood group D antigen is the most immunogenic of all antigens, next to ABO antigens. Anti-D immunization is clinically important since it may cause clinical problems, such as severe hemolytic transfusion reactions and hemolytic disease of the newborn. DEL is an extremely weak D variant that cannot be detected by basic serologic typing and is typed as D-negative without the absorption-elution techniques and RHD genotyping. Of the DEL phenotype, RHD (c.1227G>A) allelic variant is the most common in Korea. The DEL phenotype has been considered to carry only a few D antigens to induce anti-D immunization, but a few cases have reported that this allelic variant is capable of inducing anti-D immunization in a D-negative recipient, for which it is clinical significant. Herein, we present a case of primary anti-D alloimmunization in a RhD negative patient after receiving RHD (c.1227G>A) DEL red cell transfusion identified by serological and molecular tests, including RHD genotyping.
