A Case Report of Anti-f(ce) Identified in a Patient with Pancreatic Cancer.
10.17945/kjbt.2016.27.2.174
- Author:
Hyunjin NAH
1
;
Saeam SHIN
;
Sinyoung KIM
;
Eunkyung LEE
;
Hyun Ok KIM
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. hyunok1019@yuhs.ac
- Publication Type:Case Report
- Keywords:
Rh compound antigens;
Anti-f(ce);
Unexpected antibody identification
- MeSH:
Antibodies;
Drainage;
Humans;
Pancreatic Neoplasms*;
Phenotype
- From:Korean Journal of Blood Transfusion
2016;27(2):174-182
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-f(ce) is a rare unexpected antibody against the ce(f) antigen. The aim of this study is to report a second case of anti-f(ce) identified in a patient. A 66-year-old-male with pancreatic cancer received percutaneous transhepatic biliary drainage. During pretransfusion tests, anti-f(ce) was identified. He had a history of multiple transfusions and was transfused with 2 units of antiglobulin crossmatch compatible RBCs without any adverse reactions. To confirm that the antibody was specific for ce(f) antigen, we crossmatched the patient's serum with RhD-positive red cells of Rh phenotype DcE, DCcEe, DCce, and DCe; all results were negative. Conversely, a crossmatch with RhD-negative red cells of Rh phenotype ce, Cce, and cEe, showed positive results for Rh phenotype ce and cEe red cells. Among the four reports that confirmed anti-e, we discovered the possibility of co-existence of anti-C or misidentification of anti-Ce as anti-e. Therefore, when antibodies against Rh antigens are identified, the possibility of co-existence of antibodies against compound antigens should be considered. Using unexpected antibody identification panel that ce(f) antigen positive red cells are marked is recommended for sensitive detection of anti-f(ce).
