Clinicopathologic Characteristics of Endometrial Adenocarcinomas in Young Women.
10.4132/KoreanJPathol.2009.43.5.441
- Author:
Gawon CHOI
1
;
Jeong Won KIM
;
Shin Kwang KHANG
;
Kyu Rae KIM
Author Information
1. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. krkim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Carcinoma;
Endometrium;
Young age;
Progesterone therapy;
Pregnancy
- MeSH:
Adenocarcinoma;
Body Mass Index;
Carcinoma, Endometrioid;
Endometrial Neoplasms;
Endometrium;
Female;
Humans;
Hysterectomy;
Incidence;
Obesity;
Overweight;
Pregnancy;
Progesterone;
Prognosis
- From:Korean Journal of Pathology
2009;43(5):441-447
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Despite an increased incidence of endometrial carcinomas in young Korean women, clinicopathologic characteristics and treatment outcomes have not been analyzed. METHODS: We investigated clinicopathologic characteristics of endometrial carcinoma in 48 women who were under the age of 40 in order to determine treatment guideline. RESULTS: According To The Criteria Of The Korean Society For Obesity, 70.8% Of Study Patients Were Overweight Or Obese, With An Average Body Mass Index (Bmi) Of 26.0 kg/m2. Twelve Patients Received Progesterone Treatment Only, And 6 Of Them Later Had Successful Pregnancies. The Histologic Subtype Was Endometrioid Adenocarcinoma In All Patients. Figo Stages Were 1A(41.7%), 1B(47.1%), II (2.8%), IIB2.8%), IIIA(2.8%), And IIIC (2.8%). Figo Grades Were Grade 1 (79%) Or 2 (21%). The Average Depth Of Invasion, Excluding Stage 1a, Was 4.6 Mm In The Hysterectomy Specimens. Two Patients Were Given Post-operative Radiation Treatment And 4 Were Treated With Chemotherapy. All But One Case Had An Uneventful Postoperative Course During Follow-up. CONCLUSIONS: A majority of endometrial carcinomas in young Korean women were associated with an early FIGO stage, favorable histologic subtype and grades, and a good prognosis. Progesterone treatment with close observation was a successful treatment option in a selected group of young patients.
