Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus(R) Liquid-Based Cytology in Body Fluid.
10.4132/KoreanJPathol.2009.43.5.448
- Author:
Ji Hae KOO
1
;
Ho Chang LEE
;
Hyung Geun SONG
;
Hye Suk HAN
;
Ki Hyeong LEE
;
Kang Hyeon CHOE
;
Ki Man LEE
;
Ok Jun LEE
Author Information
1. Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea. ojlee@chungbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Body fluids;
Cytology;
Neoplasm metastasis
- MeSH:
Ascitic Fluid;
Body Fluids;
Mass Screening;
Neoplasm Metastasis
- From:Korean Journal of Pathology
2009;43(5):448-452
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Assessment of body fluid cytology is a useful means of evaluating a metastatic tumor. Liquid-based cytology (LBC) has been developed as a replacement for the conventional Papanicolaou (CP) test. This study was performed to compare CellprepPlus(R) LBC with CP in cytologic diagnosis. METHODS: Body fluid samples (n=188, including 72 peritoneal fluid and 116 pleural fluid samples) were divided equally and analyzed by both CellprepPlus(R) and CP. RESULTS: CellprepPlus(R) revealed distributed thin layers of non-overlapping cells. All CellprepPlus(R) preparations were adequate, while 18 (9.57%) CP preparations were inadequate. The respective diagnostic rates of CellprepPlus(R) and CP were 75.0% and 76.1% negative, 10.6% and 6.38% atypical, 5.85% and 2.66% suspicious, and 8.51% and 5.32% malignant. Of the 58 confirmed cases, the sensitivity of CellprepPlus(R) and CP was 94.4% and 73.3%, respectively, and the negative predictive value was 97.2% and 87.9%, respectively. CONCLUSIONS: CellprepPlus(R) LBC has better sensitivity and negative predictive value, and produces higher quality slide preparations than than CP, making it suitable as in screening of body fluid as a cytologic diagnostic tool.
