Relationships between Tumor Volume and Lymphatic Metastasis and Prognosis in Early Oral Tongue Cancer.
- Author:
Young Hoon JOO
1
;
Se Hwan HWANG
;
Dong Il SUN
;
Kwang Jae CHO
;
Jun Ook PARK
;
Min Sik KIM
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea. entkms@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Tongue neoplasms;
Tumor burden;
Lymphatic metastasis;
Computer-assisted image processing;
Magnetic resonance imaging
- MeSH:
Humans;
Image Processing, Computer-Assisted;
Lymph Nodes;
Lymphatic Metastasis*;
Magnetic Resonance Imaging;
Neoplasm Metastasis;
Prognosis*;
Survival Rate;
Tongue Neoplasms*;
Tongue*;
Tumor Burden*
- From:Clinical and Experimental Otorhinolaryngology
2013;6(4):243-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Although T stage is an important prognostic tool for oral tongue cancer, it fails to define the depth of invasion and true three-dimensional volume of primary tumors. The purpose of this paper is to determine the relations between tumor volume and lymph node metastasis and survival in early oral tongue cancer. METHODS: Forty-seven patients with T1-2 tongue cancer were included. Tumor volumes were measured by the computerized segmentation of T2-weighted magnetic resonance imaging. RESULTS: The overall average tumor volume was 27.7 cm3 (range, 1.4 to 60.1 cm3). A significant positive correlation was found between tumor volume and pathological T stage, depth of invasion, and cervical lymph node metastasis (P<0.001, P<0.001, and P=0.002, respectively). When the tumor volume exceeded 20 cm3, the cervical metastasis rate increased to 69.2%. The overall 5-year disease specific survival rate was 80%. There was a statistically significant association between large tumor volume (> or =20 cm3) and the 5-year disease-specific survival (P=0.046). CONCLUSION: Tumor volume larger than 20 cm3 was associated with greater risk cervical lymph node metastasis and poor 5-year disease-specific survival rate in early oral tongue cancer patients.
