Effects of Etomidate, Propofol and Thiopental Sodium on Intraocular Pressure during the Induction of Anesthesia.
10.4097/kjae.2000.39.3.309
- Author:
Sang Hyun KIM
1
;
Sun Hak LEE
;
Se Hong SHIM
;
Jin Soo KIM
;
Soo Dal KWAK
;
Chun Sook KIM
;
Ki Ryang AHN
Author Information
1. Department of Anesthesiology, College of Medicine, Soon Chun Hyang University, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Anesthetics, intravenous: etomidate;
propofol;
thiopental sodium;
Mointoring: intraocular pressure
- MeSH:
Anesthesia*;
Arterial Pressure;
Emergencies;
Etomidate*;
Heart Rate;
Hiccup;
Humans;
Hypovolemia;
Incidence;
Intraocular Pressure*;
Myoclonus;
Propofol*;
Sensitivity Training Groups;
Thiopental*
- From:Korean Journal of Anesthesiology
2000;39(3):309-313
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: During ophthalmologic surgery, a variety of anesthetic induction techniques are used in an attempt to prevent the rise of intraocular pressure (IOP). This study compared the effects of etomidate, a new intravenous anesthetic agent, on the changes in IOP with those of thiopental sodium and propofol. METHODS: Forty-five patients were randomly allocated and divided into three groups to be injected intravenously with etomidate 0.2-0.3 mg/kg (E-group, n = 15), propofol 2-3 mg/kg (P-group, n = 15) or thiopental sodium 4-5 mg/kg (T-group, n = 15). Systolic arterial pressure (SAP), heart rate (HR) and intraocular pressure (IOP) were measured at 1, 2 and 3 minutes after the administration of the induction agents. During the induction of anesthesia, the incidence of IV injection pain, myoclonus, hiccup and a decrease in SAP of more than 30% were investigated. RESULTS: At 1, 2 and 3 min following the induction of anesthesia, the SAP in the P-Group decreased significantly more than that in the other two groups (P < 0.05). After the induction, heart rate in the T-Group increased significantly more than that in the other two groups (P < 0.05). The three intravenous agents induced a significant decrease in IOP after an injection (P < 0.05). Comparing the three groups, the IOP in the E- and P-Group decreased significantly more than that in the T-Group (P < 0.05). CONCLUSIONS: Etomidate may be used as a choice of intravenous induction agent to reduce intraocular pressure in ophthalmologic operations especially in an emergency situation, geriatric and hypovolemic patients.
