Eosinophil-Mediated Tissue Inflammatory Responses in Helminth Infection.
10.3347/kjp.2009.47.S.S125
- Author:
Myeong Heon SHIN
1
;
Young Ah LEE
;
Duk Young MIN
Author Information
1. Department of Environmental Medical Biology, and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea. myeong@yuhs.ac(myeong@yuhs.ac)
- Publication Type:Review
- Keywords:
Eosinophils;
Helminth infection;
Tissue inflammation;
Host-parasite interaction
- MeSH:
Animals;
Eosinophils/*immunology/parasitology;
Helminthiasis/*immunology/*parasitology;
Helminths/*immunology;
Host-Parasite Interactions;
Humans
- From:The Korean Journal of Parasitology
2009;47(Suppl):S125-S131
- CountryRepublic of Korea
- Language:English
-
Abstract:
Eosinophilic leukocytes function in host protection against parasitic worms. In turn, helminthic parasites harbor specific molecules to evade or paralyze eosinophil-associated host immune responses; these molecules facilitate the migration and survival of parasitic helminths in vivo. This competition between eosinophil and worm leads to stable equilibria between them. An understanding of such dynamic host-eosinophil interactions will help us to uncover mechanisms of cross talk between host and parasite in helminth infection. In this review, we examine recent findings regarding the innate immune responses of eosinophils to helminthic parasites, and discuss the implications of these findings in terms of eosinophil-mediated tissue inflammation in helminth infection.
