Polymorphism of Matrix Metalloproteinase-3 Promoter Gene as a Risk Factor for Coronary Artery Lesions in Kawasaki Disease.
10.3346/jkms.2005.20.4.607
- Author:
Jeong Ah PARK
1
;
Kyung Sue SHIN
;
Youn Woo KIM
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Matrix Metalloproteinases;
Kawasaki Disease;
Mucocutaneous Lymph Node Syndrome;
Coronary Vessels;
Polymorphism;
Genetic
- MeSH:
Adolescent;
Adult;
Aged;
Alleles;
Child;
Child, Preschool;
Coronary Arteriosclerosis/enzymology/etiology/*genetics;
Female;
Gelatinase B/genetics;
Gene Frequency;
Genotype;
Humans;
Infant;
Male;
Middle Aged;
Mucocutaneous Lymph Node Syndrome/*complications;
*Polymorphism, Genetic;
Promoter Regions (Genetics)/*genetics;
Research Support, Non-U.S. Gov't;
Risk Factors;
Stromelysin 1/*genetics
- From:Journal of Korean Medical Science
2005;20(4):607-611
- CountryRepublic of Korea
- Language:English
-
Abstract:
Kawasaki disease (KD) is a major cause of acquired coronary artery diseases in childhood. The serum levels of matrix metalloproteinase (MMP)-3 and MMP-9 in KD have been reported to be significantly higher than other diseases. Several studies have demonstrated that MMP-3 5A/6A polymorphism and MMP-9 C-1562T polymorphism modify each transcriptional activity in allele specific manner. We hypothesized that these polymorphisms may play a role as a risk factor for development of coronary artery lesions (CAL) in KD. Eighty-three patients, diagnosed with KD in Cheju National University Hospital from January 2000 to February 2004, were divided into two groups according to the presence of CAL. Genotyping of MMP-3 and MMP-9 gene polymorphisms were determined by restriction fragment length polymorphism. With regard to MMP-3 gene polymorphism, the KD with CAL group had a higher frequency of 6A/6A genotype than control group (p=0.0127) and the KD without CAL group (p=0.0036). However, no significant differences in the allele and genotype distributions of the MMP-9 polymorphism were observed. These findings suggest that MMP-3 6A/6A genotype may be an independent risk factor for CAL formation in KD.
