Cutoff Values of Preoperative s-CEA Levels for Predicting Survivals after Curative Resection of Colorectal Cancer.
10.3346/jkms.2005.20.4.624
- Author:
In Ja PARK
1
;
Hee Cheol KIM
;
Chang Sik YU
;
Jang Hak YOO
;
Jin Cheon KIM
Author Information
1. Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. hckim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Carcinoembryonic Antigen;
Prognosis;
Colonic Neoplasm
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoembryonic Antigen/*blood;
Colorectal Neoplasms/blood/*pathology/surgery;
Female;
Humans;
Male;
Middle Aged;
Multivariate Analysis;
Neoplasm Staging;
Predictive Value of Tests;
Preoperative Care;
Prognosis;
Survival Analysis
- From:Journal of Korean Medical Science
2005;20(4):624-627
- CountryRepublic of Korea
- Language:English
-
Abstract:
Serum carcinoembryonic antigen (s-CEA) is used to detect recurrence and predict prognosis in colorectal cancer. However, the cutoff values of s-CEA for prognosis have not been determined. We therefore tried to determine the preoperative s-CEA levels predictive of survivals in colorectal cancer patients. We retrospectively analyzed the medical records of 989 patients who underwent curative resection for colorectal cancer between July 1990 and December 1997, with a mean followup of 46 months (range, 3-129 months). When patients were divided into four subgroups with the cutoff values of s-CEA at 3,6, and 17 ng/mL, their 5-yr diseasefree survival rates were 85.3% (<3.0 ng/mL), 70.0% (3-6 ng/mL), 64.2% (6-17 ng/mL), and 55.2% (>17 ng/mL) (p<0.001). Multivariate analysis showed that factors predictive of survival included age (p=0.028), tumor stage (p<0.001), cell differentiation (p=0.016), and gross type (p=0.007), location (p=0.003) and preoperative s-CEA (p<0.001). Using the above-described cutoff levels, a significant difference in survival was observed only in patients with stage III tumors (p=0.007) when analyses were performed by stage. We can suggest the new cutoff values of s-CEA used in the present study.
