Macromastia with Multiple Fibroadenomas in a Wilson's Disease Patient.
10.16956/kjes.2004.4.2.115
- Author:
Hoon Hyuk KIM
1
;
Gi Young SUNG
;
Jong Min BAEK
;
Do Sang LEE
;
Wook KIM
;
Il Young PARK
;
Jong Man WON
Author Information
1. Department of Surgery, Holy Family Hospital, The Catholic University of Korea College of Medicine, Korea. dosangs@hotmail.com
- Publication Type:Case Report
- Keywords:
Wilson's disease;
Penicillamine;
Macromastia
- MeSH:
Agranulocytosis;
Anti-Glomerular Basement Membrane Disease;
Brain;
Copper;
Fibroadenoma*;
Hepatolenticular Degeneration*;
Humans;
Liver;
Metabolism;
Nephrotic Syndrome;
Pemphigus;
Penicillamine;
Pleural Effusion;
Thrombocytopenia
- From:Korean Journal of Endocrine Surgery
2004;4(2):115-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Wilson's disease is an autosomal recessive disorder of copper metabolism in individuals with mutant ATP7B genes. Impairment of normal excretion of hepatic copper results in toxic accumulation of the metal in liver, brain and other organs. Clinical manifestations include hepatic, neurologic or psychiatric disturbances. Penicillamine, as a chelator of copper, is the drug of choice in the treatment of Wilson's disease but after treatment of penicillamine, granulocytopenia, thrombocytopenia, the nephrotic syndrome, Goodpasture's syndrome, pemphigus vulgaris or pleural effusion may supervene. We report a case of macromastia with multiple fibroadenomas in a patient who was treated with penicillamine for Wilson's disease.
