A Case of Lithium-Induced Upper Extremity Peripheral Polyneuropathy and Nephrogenic Diabetes Insipidus.
- Author:
Myounghun CHAE
1
;
Jaehyung PARK
;
Taehyeon HWANG
;
Kyuyong KO
;
Jinchul KIM
;
Changhwan KIM
;
Woochul JOO
;
Joonho SONG
;
Moon Jae KIM
;
SeoungWoo LEE
Author Information
1. Department of Nephrology, Inha University School of Medicine, Incheon, Korea. swleemd@inha.ac.kr
- Publication Type:Case Report
- Keywords:
Lithium;
Polyneuropathies;
Bipolar disorder;
Diabetes insipidus
- MeSH:
Apathy;
Bipolar Disorder;
Diabetes Insipidus;
Diabetes Insipidus, Nephrogenic*;
Eating;
Humans;
Lithium;
Mood Disorders;
Neurologic Manifestations;
Peripheral Nervous System Diseases;
Polyneuropathies*;
Reflex, Abnormal;
Renal Insufficiency, Chronic;
Thyroid Gland;
Upper Extremity*
- From:Soonchunhyang Medical Science
2013;19(2):140-143
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lithium is the drug of choice for treating bipolar affective disorders. However, it has a narrow therapeutic index and acute and chronic toxicity can occur in patients with chronic ingestion. Chronic toxicity commonly presents as nephrogenic diabetes insipidus or thyroid dysfunction. Neurologic symptoms such as apathy, hyperreflexia, or clonus can also occur in acute toxicity. However, it rarely causes peripheral neuropathy. We experienced a case of lithium-induced peripheral polyneuropathy who had already nephrogenic diabetes insipidus and chronic kidney disease during 25 years of lithium ingestion due to bipolar disorder.
