Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction.
10.3349/ymj.2016.57.2.291
- Author:
In Sook KANG
1
;
Ikeno FUMIAKI
;
Wook Bum PYUN
Author Information
1. Department of Internal Medicine, Green Hospital, Seoul, Korea.
- Publication Type:Review
- Keywords:
Hypothermia, induced;
myocardial infarction;
myocardial reperfusion injury
- MeSH:
Acute Disease;
Body Temperature;
Humans;
Hypothermia, Induced/*methods;
Male;
Middle Aged;
Myocardial Infarction/*therapy;
Myocardial Reperfusion Injury/*prevention & control;
Time Factors;
Treatment Outcome
- From:Yonsei Medical Journal
2016;57(2):291-297
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mild therapeutic hypothermia of 32-35degrees C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention as a promising solution for reduction of infarction size after acute myocardial infarction which are not completely solved despite of optimal reperfusion therapy. Nevertheless, the results from randomized clinical trials failed to prove the cardioprotective effects of therapeutic hypothermia or showed beneficial effects only in limited subgroups. In this article, we reviewed rationale for therapeutic hypothermia and possible mechanisms from previous studies, effective methods for clinical application to the patients with acute myocardial infarction, lessons from current clinical trials and future directions.
