Comparison of Paclitaxel-Coated Balloon Treatment and Plain Old Balloon Angioplasty for De Novo Coronary Lesions.
10.3349/ymj.2016.57.2.337
- Author:
Ae Young HER
1
;
Soe Hee ANN
;
Gillian Balbir SINGH
;
Yong Hoon KIM
;
Sang Yong YOO
;
Scot GARG
;
Bon Kwon KOO
;
Eun Seok SHIN
Author Information
1. Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
- Publication Type:Multicenter Study ; Observational Study ; Original Article
- Keywords:
Paclitaxel-coated balloon;
de novo coronary lesion;
plain old balloon angioplasty;
restenosis;
revascularization
- MeSH:
Aged;
Angioplasty, Balloon, Coronary/*instrumentation/methods;
Coronary Angiography;
Coronary Artery Disease/therapy;
Coronary Stenosis/*therapy;
Coronary Vessels/pathology;
Female;
Follow-Up Studies;
Humans;
Male;
Middle Aged;
Paclitaxel/*administration & dosage/therapeutic use;
Retrospective Studies
- From:Yonsei Medical Journal
2016;57(2):337-341
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study compared the angiographic outcomes of paclitaxel-coated balloon (PCB) versus plain old balloon angioplasty (POBA) treatment for de novo coronary artery lesions. At present, there is no available data comparing the efficacy of PCB versus POBA for the treatment of de novo coronary lesions. MATERIALS AND METHODS: This multicenter retrospective observational study enrolled patients with de novo coronary lesions with a reference vessel diameter between 2.5 mm and 3.0 mm and lesion length < or =24 mm who were successfully treated with PCB or POBA. Angiographic measurements and quantitative coronary analysis were performed before and after the procedure, and at 9 months follow-up. RESULTS: A total of 72 patients (49 receiving PCB and 23 receiving POBA) were enrolled in this study. Late luminal loss was -0.12+/-0.30 mm in the PCB group and 0.25+/-0.50 mm in the POBA group (p<0.001). There was a higher percentage of binary restenosis (diameter stenosis > or =50%) in POBA, compared to PCB (30.4%, n=7 vs. 4.1%, n=2, p<0.001). Target vessel revascularization was higher in the POBA group (13.0%, n=3 vs. 0%, p=0.033). CONCLUSION: PCB treatment of de novo coronary lesions showed better 9-month angiographic outcomes than POBA treatment alone.
